Marieke Niesters Selected Research

Respiratory Insufficiency (Respiratory Failure)

7/2023	Pharmacology of viable mechanism agnostic respiratory stimulants for the reversal of drug-induced respiratory depression in humans.
4/2023	A biomarker of opioid-induced respiratory toxicity in experimental studies.
1/2023	Oral Oxycodone-Induced Respiratory Depression During Normocapnia and Hypercapnia: A Pharmacokinetic-Pharmacodynamic Modeling Study.
1/2023	Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest.
1/2023	Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine.
1/2023	Inhaled Δ9-tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression: randomised controlled trial in healthy volunteers.
10/2022	Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression.
1/2022	Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity.
1/2022	Are thyrotropin-releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid-induced respiratory depression?
1/2022	Respiratory effects of thyrotropin-releasing hormone and its analogue taltirelin on opioid-induced respiratory depression.

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Marieke Niesters Research Topics

Disease

35	Pain (Aches) 04/2024 - 10/2010
27	Respiratory Insufficiency (Respiratory Failure) 07/2023 - 01/2012
21	Chronic Pain 01/2023 - 10/2010
12	Neuralgia (Stump Neuralgia) 04/2024 - 07/2011
9	Hyperalgesia 01/2020 - 07/2011
8	Fibromyalgia (Fibrositis) 04/2024 - 10/2011
5	Apnea 07/2023 - 01/2021
5	Postoperative Pain 12/2020 - 01/2016
5	Acute Pain 01/2017 - 07/2011
4	Complex Regional Pain Syndromes 04/2015 - 03/2011
3	Opiate Overdose 02/2024 - 01/2019
3	Cancer Pain 01/2017 - 10/2010
2	Nausea 01/2018 - 02/2014
2	Peripheral Nerve Injuries 07/2016 - 11/2011
2	Sarcoidosis (Schaumann Disease) 07/2016 - 11/2013
2	Hallucinations (Hallucination) 12/2015 - 02/2014
1	Drug Overdose 07/2023
1	Heart Arrest (Cardiac Arrest) 01/2023
1	Hypercapnia 01/2023
1	Myasthenia Gravis 01/2022
1	Opioid-Related Disorders (Opiate Addiction) 01/2022
1	Osteoarthritis 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Low Back Pain (Lumbago) 11/2020
1	Poisoning 01/2020
1	Bites and Stings (Sting) 01/2020
1	Chronic Pancreatitis 11/2019
1	Dizziness (Lightheadedness) 11/2019
1	Hypoxia (Hypoxemia) 01/2019
1	Hypotension (Low Blood Pressure) 01/2019
1	Back Pain (Backache) 01/2019
1	Rheumatoid Arthritis 01/2019
1	Alcoholism (Alcohol Abuse) 01/2019
1	Drug-Related Side Effects and Adverse Reactions 01/2018
1	Type 2 Diabetes Mellitus (MODY) 07/2016
1	Small Fiber Neuropathy 07/2016
1	Hypertension (High Blood Pressure) 01/2016
1	Tachycardia (Tachyarrhythmias) 01/2016

Drug/Important Bio-Agent (IBA)

35	Opioid Analgesics (Opioids)IBA 04/2024 - 10/2010
22	Ketamine FDA LinkGeneric 01/2022 - 10/2010
14	Analgesics (Analgesic Drugs)IBA 01/2023 - 10/2010
9	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2019 - 10/2010
8	Morphine (MS Contin)FDA LinkGeneric 01/2023 - 10/2010
8	Fentanyl (Sublimaze)FDA LinkGeneric 01/2022 - 03/2013
5	Naloxone (Narcan)FDA LinkGeneric 02/2024 - 01/2012
5	EsketamineIBA 09/2012 - 03/2011
4	Oxycodone (Oxycontin)FDA LinkGeneric 01/2023 - 03/2017
4	cibinetideIBA 07/2016 - 11/2011
3	Biomarkers (Surrogate Marker)IBA 04/2023 - 01/2015
3	Opioid Receptors (Opioid Receptor)IBA 01/2022 - 01/2012
3	norketamineIBA 01/2022 - 07/2011
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2021 - 01/2018
3	Tapentadol FDA Link 11/2020 - 01/2015
3	Peptides (Polypeptides)IBA 02/2014 - 11/2011
2	Respiratory System Agents (Respiratory Stimulants)IBA 07/2023 - 01/2018
2	Carbon DioxideIBA 01/2023 - 01/2019
2	Dronabinol (THC)FDA LinkGeneric 01/2023 - 04/2019
2	((3- methoxythiophen- 2- yl)methyl)((2- (9- (pyridin- 2- yl)- 6- oxaspiro(4.5)decan- 9- yl)ethyl))amineIBA 01/2023 - 01/2020
2	Alfentanil (Alfenta)FDA LinkGeneric 10/2022 - 01/2018
2	Remifentanil (Ultiva)FDA Link 10/2022 - 01/2022
2	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2022 - 01/2022
2	SugammadexIBA 01/2022 - 01/2019
2	Buprenorphine (Subutex)FDA LinkGeneric 01/2022 - 01/2022
2	Thyrotropin-Releasing Hormone (Protirelin)FDA Link 01/2022 - 01/2022
2	Neostigmine (Neostigmine Bromide)IBA 01/2022 - 01/2019
2	Sufentanil (Sufenta)FDA LinkGeneric 01/2022 - 01/2018
2	insulin receptor-related receptor (IRR)IBA 07/2016 - 01/2013
2	Erythropoietin FDA Link 02/2014 - 11/2011
1	aminoalcoholphosphotransferase (AAPT)IBA 04/2024
1	GTP-Binding Proteins (G-Protein)IBA 01/2023
1	tianeptine (Stablon)IBA 10/2022
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 10/2022
1	AcidsIBA 10/2022
1	Antidepressive Agents (Antidepressants)IBA 10/2022
1	LigandsIBA 01/2022
1	Prednisolone (Predate)FDA LinkGeneric 01/2022
1	Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric 01/2022
1	Sevoflurane (Ultane)FDA LinkGeneric 12/2020
1	18,19-dihydroetorphine (dihydroetorphine)IBA 12/2019
1	Pregabalin (Lyrica)FDA Link 11/2019
1	CannabinoidsIBA 04/2019
1	Rocuronium (Zemuron)FDA LinkGeneric 01/2019
1	Neuromuscular Blocking AgentsIBA 01/2019
1	Atropine FDA LinkGeneric 01/2019
1	TabletsIBA 01/2018
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2018
1	Therapeutic UsesIBA 01/2018
1	Ethanol (Ethyl Alcohol)IBA 03/2017

Therapy/Procedure

19	Analgesia 11/2020 - 10/2010
7	Therapeutics 01/2022 - 03/2013
4	Anesthesia 01/2022 - 01/2019
3	Spinal Anesthesia 01/2022 - 08/2014
2	Drug Therapy (Chemotherapy) 01/2022 - 04/2015
2	Aftercare (After-Treatment) 01/2015 - 07/2011
1	Injections 01/2022
1	Investigational Therapies (Experimental Therapy) 01/2022
1	Activities of Daily Living (ADL) 01/2020
1	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 01/2018
1	Pain Management 01/2018
1	Orthopedic Procedures 01/2018